abstract：:Irrespective of the method used for noninvasive bone mass determination, data comparison between different centers is a major problem as significant interunit variation may occur. We, therefore, have employed mobile densitometry units to reduce interunit variability in two large epidemiologic studies in Germany. Two c...

journal_title：Calcified tissue international

authors： Wapniarz M,Lehmann R,Randerath O,Baedeker S,John W,Klein K,Allolio B

更新日期：1994-03-01 00:00:00

abstract：:KH1060 is a new 20-epi-vitamin D3 analog, which has exerted a considerable immunosuppressive potency in vitro. We have tested in vivo the effect of KH1060 on the suppression of renal allograft rejection in the rat. Allogenic kidney transplantation from DA donor rats to Lewis recipient rats treated intraperitoneally wi...

journal_title：Calcified tissue international

authors： Lewin E,Olgaard K

更新日期：1994-02-01 00:00:00

abstract：:Carboxy-terminal pyridinoline cross-linked telopeptide of type I collagen (ICTP) in serum has recently been proposed as a new biochemical marker of bone resorption. In the present study we compared serum ICTP with radiopharmaceutical and histomorphometric measurements of bone turnover in postmenopausal women with mild...

journal_title：Calcified tissue international

authors： Hassager C,Jensen LT,Pødenphant J,Thomsen K,Christiansen C

更新日期：1994-01-01 00:00:00

abstract：:We studied the relationship between serum calcium (Ca) and parathyroid hormone (PTH) in patients with idiopathic hypoparathyroidism (IHP) to investigate the diversity of the degree of parathyroid insufficiency and a regulation of PTH secretion by Ca in IHP. Serum intact PTH concentrations ranged from < 1.0 to 10.3 pg/...

journal_title：Calcified tissue international

authors： Mizunashi K,Furukawa Y,Abe K,Yoshinaga K

更新日期：1993-12-01 00:00:00

abstract：:The purpose of the present study was to determine if the type of dietary fat can modify the fatty acid composition and arachidonic acid levels in the alveolar bone phospholipids. Three groups of rats were fed nutritionally adequate semipurified diets containing different lipids: 10% corn oil (control, group I, rich in...

journal_title：Calcified tissue international

authors： Alam SQ,Kokkinos PP,Alam BS

更新日期：1993-11-01 00:00:00

abstract：:Effects of a single dose of 200 IU of nasal salmon calcitonin (SCT) on calcium metabolism and biochemical markers of bone turnover were investigated in 12 healthy male volunteers in a randomized, placebo-controlled, cross-over design. The nasal spray was given in the morning, and subsequently blood and urine samples w...

journal_title：Calcified tissue international

authors： Thamsborg G,Skousgaard SG,Daugaard H,Schifter S,Kollerup G,Sørensen OH

更新日期：1993-10-01 00:00:00

abstract：:Molybdenum (Mo), at high concentrations, induces changes in the epiphyseal growth plate through its effects on copper (Cu) metabolism but it is unclear whether or not Mo can induce changes independent of its effects on copper status. To this end, the effect of Mo on longitudinal bone growth was examined in rats. Dieta...

journal_title：Calcified tissue international

authors： Parry NM,Phillippo M,Reid MD,McGaw BA,Flint DJ,Loveridge N

更新日期：1993-09-01 00:00:00

abstract：:We examined the osteogenesis process in transforming growth factor beta 1 (TGF-beta 1)-treated neonatal and adult rats, aiming to investigate the age difference in the effect of TGF-beta 1 on mesenchymal cell differentiation. Recombinant human (rh) TGF-beta 1 (20 and 200 ng) was injected onto the outer periostea of th...

journal_title：Calcified tissue international

authors： Taniguchi Y,Tanaka T,Gotoh K,Satoh R,Inazu M

更新日期：1993-08-01 00:00:00

abstract：:Bone tissue is a source of growth factors; among them, insulinlike growth factor I (IGF-I) is probably an important local regulator of bone formation. This study has been carried out in order to assess the effects of natural menopause on plasma concentrations of IGF-I in the first 6 years after the cessation of gonada...

journal_title：Calcified tissue international

authors： Romagnoli E,Minisola S,Carnevale V,Scarda A,Rosso R,Scarnecchia L,Pacitti MT,Mazzuoli G

更新日期：1993-07-01 00:00:00

abstract：:Targeted disruption of the c-src gene leads to a severe form of osteopetrosis in mice [2]. As the c-src gene is expressed in all tissues and cells tested, we have analyzed fibroblasts from three individuals with malignant, congenital osteopetrosis for the expression of c-src at the protein level. No differences could ...

journal_title：Calcified tissue international

authors： Meyerson G,Dahl N,Påhlman S

更新日期：1993-07-01 00:00:00

abstract：:Synovial fluid basic calcium phosphate (BCP) crystals are associated with severe destructive arthropathy. BCP crystals induce the secretion of matrix-degrading enzymes such as collagenase. No prophylactic or therapeutic agents are recognized to ameliorate the cartilage damage associated with BCP deposits in joints. As...

journal_title：Calcified tissue international

authors： McCarthy GM,Mitchell PG,Cheung HS

更新日期：1993-06-01 00:00:00

abstract：:The aim of our study was to compare the results provided by the measurement of vertebral and femoral bone mineral density (BMD) for assessing the individual risk of osteoporosis as defined by either low BMD and/or rapid bone loss. Vertebral and femoral BMD were measured twice at a mean interval of 21 months in 85 norm...

journal_title：Calcified tissue international

authors： Pouilles JM,Tremollieres F,Ribot C

更新日期：1993-05-01 00:00:00

abstract：:Condylar cartilages were cultured in the form of organ cultures on top of collagen sponges in medium containing 2% fetal calf serum and were treated with 3.5-350 nM insulin for 6 days. Doses of 175 nM of insulin caused a marked increase (+96%) in DNA synthesis and in proteoglycan production (+74%), features that manif...

journal_title：Calcified tissue international

authors： Maor G,Silbermann M,von der Mark K,Heingard D,Laron Z

更新日期：1993-04-01 00:00:00

abstract：:We measured serum concentrations of bone Gla-protein (osteocalcin, BGP) and carboxyterminal propeptide of type I procollagen (PICP) in 14 patients with active acromegaly. Blood was collected at 0800 for measurement of bone Gla-protein (BGP), carboxyterminal propeptide of type I procollagen (PICP), and insulin-like gro...

journal_title：Calcified tissue international

authors： Terzolo M,Piovesan A,Osella G,Pia A,Reimondo G,Pozzi C,Raucci C,Torta M,Paccotti P,Angeli A

更新日期：1993-03-01 00:00:00

abstract：:The aim of this work was a preliminary assessment of the feasibility of using in vivo measurements of mechanical properties of bones to detect mineral loss and further to relate them to the tendency of the bone to fracture in the case of loss of minerals, such as in osteoporosis. Previous studies of bone strength in v...

journal_title：Calcified tissue international

authors： Dimarogonas AD,Abbasi-Jahromi SH,Avioli LV

更新日期：1993-03-01 00:00:00

abstract：:Osteonectin, gamma-carboxyglutamic acid-containing (Gla) protein, and dentin phosphoprotein were covalently attached to sepharose beads and inoculated in solutions at two different degrees of supersaturation with respect to both octacalcium phosphate (OCP) and hydroxyapatite. In both solutions, the inhibitory activity...

journal_title：Calcified tissue international

authors： Doi Y,Horiguchi T,Kim SH,Moriwaki Y,Wakamatsu N,Adachi M,Shigeta H,Sasaki S,Shimokawa H

更新日期：1993-02-01 00:00:00

abstract：:The histologic heterogeneity of osteoporosis relative to normal controls has attracted great interest. There has been controversy as to whether patients with high turnover osteoporosis may convert to a normal or low turnover form, and vice versa. We have studied 44 patients over 12 years by dynamic histomorphometry an...

journal_title：Calcified tissue international

authors： Arlot ME,Bradbeer JN,Edouard C,Green JR,Hesp R,Roux JP,Meunier PJ,Reeve J

更新日期：1993-01-01 00:00:00

abstract：:Healing trabecular microfractures are a common feature in cancellous bone. These lesions, when observed in macerated cancellous bone slices, measure about 500 microns in diameter and surround fractures in trabeculae with microcallus. Whether microcallus is a structure acting primarily as a transient brace, preventing ...

journal_title：Calcified tissue international

authors： Fazzalari NL

更新日期：1993-01-01 00:00:00

abstract：:A comparative polarized light (PLM), scanning (SEM), and transmission (TEM) electron microscopy study was carried out on cross- and longitudinal sections of human lamellar bone in the tibiae of four male subjects aged 9, 23, 45, and 70 years. SEM analysis was also performed on rectangular-prismatic samples in order to...

journal_title：Calcified tissue international

authors： Marotti G

更新日期：1993-01-01 00:00:00

abstract：:This study examined effects of bone bonding and nonbonding implants on parameters associated with matrix vesicle-mediated primary bone formation, matrix vesicle alkaline phosphatase and phospholipase A2 specific activities, and phosphatidylserine content. Tibia marrow ablation followed by implantation of KG-Cera, Mina...

journal_title：Calcified tissue international

authors： Schwartz Z,Swain LD,Marshall T,Sela J,Gross U,Amir D,Muller-Mai C,Boyan BD

更新日期：1992-12-01 00:00:00

abstract：:Human osteoblasts were obtained by migration and proliferation of cells from embryonic membranous bone on glass fragments. Light and electron microscopy analyses revealed a typical osteoblast-like appearance with high protein synthesis activity. The cells showed high alkaline phosphatase activity that was associated w...

journal_title：Calcified tissue international

authors： Oliva A,Marrone G,Della Ragione F,Riccio V,Palumbo R,Rossano F,Zappia V

更新日期：1992-11-01 00:00:00

abstract：:Plasma membrane vesicles were prepared from chicken osteoclasts, and active calcium transport was demonstrated in a spectrofluorimetric assay using the fluorescent calcium concentration indicator, fura-2. Transport activity was inhibited by quercetin (10 microM), sodium vanadate (10 microM), and the anticalmodulin age...

journal_title：Calcified tissue international

authors： Bekker PJ,Gay CV

更新日期：1992-10-01 00:00:00

abstract：:Ribbon-like crystals, from developing enamel of human fetuses, were studied by high resolution electron microscopy. These crystals were classically described as the first organized mineral formed during amelogenesis. They were characterized by a mean width-to-thickness ratio (W.T-1) of 9.5, and 40% were bent. On latti...

journal_title：Calcified tissue international

authors： Cuisinier FJ,Steuer P,Senger B,Voegel JC,Frank RM

更新日期：1992-10-01 00:00:00

abstract：:Five years ago we reported results from a cross-sectional study of the effect of nutritional factors on calcium-regulating hormones and bone loss in perimenopausal women. We found an inverse correlation between serum 25-hydroxyvitamin D (25OHD) and immunoreactive parathyroid hormone (PTH), and we postulated that over ...

journal_title：Calcified tissue international

authors： Lukert B,Higgins J,Stoskopf M

更新日期：1992-09-01 00:00:00

abstract：:A 69-year-old man became hypocalcemic under medical observation. The hypocalcemia occurred in the presence of circulating immunoreactive parathyroid hormone (PTH). Common causes of secondary hyperparathyroidism were excluded, as was PTH resistance using PTH infusions. The immunoreactive PTH was examined in detail. PTH...

journal_title：Calcified tissue international

authors： McElduff A,Lackmann M,Wilkinson M

更新日期：1992-08-01 00:00:00

abstract：:We treated four hypercalcemic cancer patients by nasal hCT, 3 x 2 mg daily, which has been reported to be active in Paget's disease at lower doses. Only one patient became normocalcemic and mean (+/- SEM) calcium levels fell from 11.6 +/- 0.2 mg/dl before therapy to 10.7 +/- 0.6 mg/dl 2-3 days after starting hCT. The ...

journal_title：Calcified tissue international

authors： Dumon JC,Magritte A,Body JJ

更新日期：1992-07-01 00:00:00

abstract：:A simple method for determining histamine and polyamines in various tissues was devised. The method, however, could not be applied to calcified tissues, because the high concentration of Ca2+ in the extract interferes with the chromatographic separation of these amines. By treating the extracts from calcified tissues ...

journal_title：Calcified tissue international

authors： Endo Y,Kikuchi T,Nakamura M,Shinoda H

更新日期：1992-07-01 00:00:00

abstract：:The phorbol ester 12-O-tetradecanoyl-13-acetate (TPA) blocked the growth of, and induced the appearance of processes in the human osteosarcoma cell line U-2 OS. The phorbol ester decreased the intracellular level of alkaline phosphatase (APase) activity (as measured per mg cell protein) and caused a marked increase in...

journal_title：Calcified tissue international

authors： Ringbom-Anderson T,Akerman KE

更新日期：1992-06-01 00:00:00

abstract：:The effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) (2.3 x 10(-12) - 1.4 x 10(-6) [M]) on alkaline phosphatase, collagen, and cell proliferation were examined in primary cultured hypertrophic chondrocytes prepared from the distal epiphyseal growth plate of the tibias of 12-day chick embryos. 1,25(OH)2D3 showed time-...

journal_title：Calcified tissue international

authors： Inao S,Conrad HE

更新日期：1992-05-01 00:00:00

abstract：:Prostaglandin E2 and leukotriene B4 are metabolites of arachidonic acid with well-characterized effects on osteoblastic cells. Prostaglandin E2 has been shown to be a potent bone-resorbing agent and to stimulate as well as inhibit osteoblastic cell proliferation. Leukotriene B4 has also been demonstrated to stimulate ...

journal_title：Calcified tissue international

authors： Ren W,Kinniburgh AJ,Dziak R

更新日期：1992-04-01 00:00:00

abstract：:There are few studies of the effect of smoking on bone density in young women. The reported antiestrogenic effect of smoking could be a mechanism for a possible effect of smoking on bone. We measured bone mineral density (BMD) by dual-energy X-ray absorptiometry (whole body, proximal femur, lumbar spine), and serum le...

journal_title：Calcified tissue international

authors： Daniel M,Martin AD,Drinkwater DT

更新日期：1992-04-01 00:00:00

abstract：:The present report compares the effects of different membrane phospholipid (PL)-cholesterol compositions on the kinetics of liposome-mediated formation of calcium phosphates from metastable solutions (2.25 mM CaCl2; 1.5 mM KH2PO4) at 22 degrees C, pH 7.4 and 240 mOsm. In most experiments, the liposomes were composed o...

journal_title：Calcified tissue international

authors： Skrtic D,Eanes ED

更新日期：1992-03-01 00:00:00

abstract：:To study the mechanism of action of thyroid hormones on bone, we examined the effects of immunosuppressive and nonimmunosuppressive cyclosporins, as well as of transforming growth factor beta 1 (TGF beta 1), 17 beta-estradiol (E2), and dihydroxytestosterone (DHT) on thyroxine (T4)- and triiodothyronine (T3)-stimulated...

journal_title：Calcified tissue international

authors： Lakatos P,Stern PH

更新日期：1992-02-01 00:00:00

abstract：:Bone labeling, histochemical, and fine structural studies were performed in order to clarify the effects of ipriflavone (IP) on rat bone tissue in vivo and in vitro. Labeling experiments showed a slight increase in bone formation during 3 days' administration. It was also noted that many osteoclasts detached from the ...

journal_title：Calcified tissue international

authors： Ozawa H,Nakamura H,Irie K,Irie M

更新日期：1992-01-01 00:00:00

abstract：:Doses of 8, 16 (low), 32, 48, 64 (medium), and 150 (high) mg/kg/day of cortisol were administered to groups of 8 growing rats each during 16 days, and their femurs were then submitted to 3-point bending tests at low strain rate. Low doses had no effect. Medium doses, previously shown to improve calcium (Ca) balance an...

journal_title：Calcified tissue international

authors： Ferretti JL,Vázquez SO,Delgado CJ,Capozza R,Cointry G

更新日期：1992-01-01 00:00:00

abstract：:We examined the role of sleep, growth hormone (GH), and parathyroid hormone [PTH(1-84)] as regulators of the diurnal rhythm of the osteoblastic bone marker, serum osteocalcin (OC). Nine normal subjects were followed with hourly blood sampling during one 24-hour period with normal sleep pattern, and one 24-hour period ...

journal_title：Calcified tissue international

authors： Nielsen HK,Brixen K,Kassem M,Christensen SE,Mosekilde L

更新日期：1991-12-01 00:00:00

abstract：:The pharmacokinetics and bioavailability of pamidronate were assessed in patients with breast cancer, 6 subjects received the drug intravenously and 7 orally. The initial plasma half-life of pamidronate was short (42 +/- 27 min) and the apparent total plasma clearance was high (471 +/- 298 ml/min). The renal clearance...

journal_title：Calcified tissue international

authors： Daley-Yates PT,Dodwell DJ,Pongchaidecha M,Coleman RE,Howell A

更新日期：1991-12-01 00:00:00

abstract：:Dual photon absorptiometry (DPA) is currently the most widely used method for noninvasive bone mineral density (BMD) measurement of the axial skeleton. Dual energy X-ray absorptiometry (DEXA) is a recently developed technique that uses an X-ray tube as a photon source; it has demonstrated several significant advantage...

journal_title：Calcified tissue international

authors： Holbrook TL,Barrett-Connor E,Klauber M,Sartoris D

更新日期：1991-11-01 00:00:00

abstract：:Osseous tissue develops via two distinctly different processes: endochondral (EC) ossification and intramembranous (IM) ossification. The present study tests the hypothesis that each type of osseous tissue contains unique inducing factors for the promotion of cartilage and bone development. Previous work suggests that...

journal_title：Calcified tissue international

authors： Scott CK,Hightower JA

更新日期：1991-11-01 00:00:00

abstract：:A resolution-enhanced Fourier Transform Infrared (FTIR) Spectroscopic study of the CO3(2-) ion in pig enamel of increasing age and maturity has demonstrated the existence of four different, main carbonate locations. The major CO3(2-) site arises as a result of the substitution of CO3(2-) ions in the positions occupied...

journal_title：Calcified tissue international

authors： Rey C,Renugopalakrishnan V,Shimizu M,Collins B,Glimcher MJ

更新日期：1991-10-01 00:00:00